The third-seeded Rams (23-2), who are ranked eighth in the state in the latest poll, will be at home against the 19th-seeded Bulls (14-9) from Delaware County in a 7 p.m. start.
In the opening round, Glen Mills defeated Harry S Truman, 62-61, in overtime Friday night.
Kenny Rogers is the leading scorer for the Bulls at 13.6 points per game in a balanced attack for coach Craig Mellinger.
Jermaine Pierce, an outstanding leaper, tallied 22 points in the victory over Truman and Jose Iberra had 13. Ricky Love is another potential double-figure scorer who had 12 in a victory over Sun Valley.
Spring-Ford held off Central Bucks West, 59-56, in the first round after building a 17-point lead. The Rams are led in scoring by senior forwards Ryan Kraft (17.0, 80 treys) and Tom Murphy (14.5).
The other starters for coach Dave Caldwell are guards Drew Kurtz and Julius Lopez and center Carl Grzywacz. The bench includes Mike Krajnik, Billy Mengel, Eric Burnett (21 triples), Mark Cooper and Matt Davisson.
The PAC-10 champion Rams must win this game in order to have a chance to qualify for one of seven district berths in the state tournament.
"They are a typical Glen Mills team," Caldwell said. "They are athletic, scrappy, hustle and quick. They present a lot of problems. They have balanced scoring, and sometimes that can create even more of a problem. They beat Truman, which is a very good team.
"Craig Mellinger and his staff do a great job. It is a big, big challenge for us. We can't throw it around the last couple minutes like we did in the C.B. West game or we go home with an 'L' with their speed and quickness."