The new system was expected to include a wintry mix of elements before changing into snow late Tuesday. Much of the state could get about 6 inches of snow, said Mike Gorse, a meteorologist with the National Weather Service.
The first storm, which began Sunday night and continued into Monday morning, led to hundreds of school closures and numerous traffic accidents - including one involving several tractor trailers on the Pennsylvania Turnpike.
Most of the Philadelphia area received between 2 and 4 inches, forecasters said, with about 4 to 6 inches reported in parts of western Pennsylvania and 3 to 4 in the Harrisburg area.
But a new challenge begins Tuesday when a second batch of sleet, freezing rain and snow enters the state. The snow is expected to pick up in intensity late in the day and taper off on Wednesday.
"Freezing rain will hold down snow accumulation, but it will make conditions for traveling" difficult, said Bob Reed, a weather service meteorologist. "It's going to be at least a nuisance."
Dennis Narey, emergency operations manager for the Allegheny County Emergency Agency, estimated that have been "over 100" traffic accidents in the county, most of them minor.
"One of the things we try to do is encourage people (if) there's no need to leave home, stay home during these kinds of incidents," he said.
Passengers at Philadelphia International Airport experienced minor delays and cancellations, with less than 5 percent of total traffic affected by the weather, spokesman Mark Pesce said Monday morning.
Schools in Philadelphia and Pittsburgh were also closed on Monday.
Crews with the Pennsylvania Department of Transportation were preparing for additional accumulation. Workers in District 6, which encompasses the five-county Philadelphia region, have 430 salt trucks at their disposal.
"What's coming next, if it's just ice, will be just salting - very little plowing will be taking place then," said Charles Metzger, a district spokesman.
In District 11, which includes Lawrence, Allegheny and Beaver counties, crews responsible for covering 60 routes and about 5,000 miles of roadway are working 12-hour shifts, said PennDOT spokesman Dick Skrinjar.
The turnpike accident occurred in Butler County around 11:30 a.m. and involved three tractor trailers. No injuries were reported, state police said.
Debbie Beck, a spokeswoman for Allegheny Power, said roughly 60 of the utility's customers were temporarily without power Monday. Peco Energy, the southeastern Pennsylvania utility, had a "good morning" Tuesday and was not reporting power outages among its customers, spokesman Michael Wood said.
Meanwhile, in downtown Philadelphia, as some pedestrians gingerly crossed wet crosswalks, many shrugged off the weather as a routine part of winter.
"We're very fortunate. A lot of people deal with this on an almost everyday basis," said Carl Hunter, 43, of Philadelphia.